Leg veins: the nemesis of women over 40! We really notice our leg veins and spider in spring and summer; but the best time to get rid of them is fall and winter. Spider vein treatment often results in some bruising and discoloration for 1-3 weeks. And then it can take 2-3 months to see the full results of the treatment. Also, more than one treatment is usually needed. That’s why there’s no better time than now to start!